View: BioActivity Assays help


Therapeutic Assays help :

# Assay ID Compound tested
active|inactive
Type Assay Title View Enriched Targets/Pathways
1 449763 1125|330634 CHOP_apoptosis uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay view
2 434962 1316|323541 Diabetes Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) view
3 1273 1153|126162 Diabetes Primary screen for compounds that inhibit Insulin promoter activity in TRM-6 cells view
4 743287 2292|371892 Diabetes Luminescent GLuc Reporter Gene Assay Primary HTS to Identify Small Molecule Activator of Glucose Dependent Insulin Secretion Measured in Cell-Based System Using Plate Reader - 7055-01_Activator_SinglePoint_HTS_Activity view
5 1625 574|191406 Diabetes HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 Cells view
6 1296 1039|126117 Diabetes Primary screen for compounds that activate Insulin promoter activity in TRM-6 cells view
7 1628 927|190531 Diabetes HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells view
8 493087 245|335216 Diabetes Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) view
9 1159537 367|43347 Diabetes qHTS screening for TAG (triacylglycerol) accumulators in algae view
10 435005 2443|301016 Diabetes Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. view
11 2380 956|329523 Diabetes uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line view
12 651582 1501|225360 Diabetes uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay view
13 1381 1035|218979 Dynein_Cargo HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. view
14 1865 543|271137 Epigenetic Quantitative High-Throughput Screen for Regulators of Epigenetic Control view
15 743247 297|345074 FN_fibrillogenesis Inhibition of Alexa 488-Fibronectin deposition #on AH1F cell monolayers Measured in Cell-Based System Using Plate Reader - 7059-01_Inhibitor_SinglePoint_HTS_Activity view
16 720488 959|15038 FalsePositive Fluorescence-based counterscreen assay for HCV NS3 helicase inhibitors of a ChemBridge library: biochemical high-throughput screening assay to identify compounds that cause fluorescent interference view
17 593 537|39192 FalsePositive qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region view
18 1776 489|194272 FalsePositive Profiling compound fluorescence on GSH Beads with 488 nm excitation and 530 nm emission view
19 709 3590|61854 FalsePositive Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm view
20 1775 825|216798 FalsePositive Profiling compound fluorescence on Avidin Beads with 488 nm excitation and 530 nm emission view
21 589 6249|47667 FalsePositive qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region view
22 590 6462|43846 FalsePositive qHTS Assay for Spectroscopic Profiling in A350 Spectral Region view
23 624168 805|363362 Glycosylation uHTS identification of small molecule activators of alpha dystroglycan glycosylation view
24 588692 830|356987 Glycosylation Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 view
25 739 875|96643 Golgi_Transport Modulators of Post-Golgi Transport view
26 738 4851|92676 Golgi_Transport Screening for Modulators of Post-Golgi Transport, Control Strain view
27 2313 458|20860 Hedgehog Luminescence Cell-Based Primary HTS to Identify Inhibitors of the Sonic Hedgehog Signaling Pathway view
28 645 448|64192 Her_Kinase_Expr Isolation of Inhibitors of Her-Kinase Expression - 66K library screen view
29 595 308|67116 Hsp90_Chaperone qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction view
30 1224844 617|7974 Hypoxia qHTS assay to identify small molecule agonists of the hypoxia (HIF-1) signaling pathway - cell viability counter screen view
31 914 223|7902 Hypoxia qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway view
32 1910 950|299206 Hypoxia Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway view
33 915 455|7902 Hypoxia qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway view
34 588492 2272|357248 Ischemia uHTS identification of small molecule modulators of myocardial damage view
35 1362 4012|190222 Mitochon_Fusion Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen view
36 485298 739|315993 Mitochon_Fusion qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion view
37 624291 222|332000 MuscularDystrophy qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy view
38 435003 1736|328743 NFkB_activation uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation view
39 435022 1079|330679 NFkB_activation uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation view
40 1460 5823|221865 Neuro qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding view
41 1468 1070|255062 Neuro qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization view
42 1463 2576|251621 Neuro Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization view
43 1814 21692|277104 Parkinson MLPCN Alpha-Synuclein 5&apos view
44 1813 2501|300874 Parkinson MLPCN Alpha-Synuclein 5&apos view
45 488862 1169|333842 Prion Inhibitors of Prion Protein 5&apos view
46 720596 1597|368677 Prion TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) view
47 1053188 780|82225 R_arthritis Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based System Using Plate Reader - 7124-01_Inhibitor_SinglePoint_HTS_Activity view
48 1458 5854|193074 SpinalAtrophy qHTS Assay for Enhancers of SMN2 Splice Variant Expression view
49 775 904|131891 aging Screen for Chemicals that Extend Yeast Lifespan view
50 804 710|138047 aging Screen for Chemicals that Shorten Yeast Lifespan view
51 2690 590|328352 aging A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide view
52 588674 1846|355142 bone_formation Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 view
53 827 1659|136778 cancer High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor view
54 686970 5978|331368 cancer qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line view
55 624156 901|44624 cancer Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity view
56 429 223|63693 cancer HTS for Tumor Hsp90 Inhibitors view
57 651958 2045|367198 cancer Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate view
58 686971 7451|328240 cancer qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line view
59 818 2052|136705 cancer High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression view
60 2685 2061|149192 lipid_droplet qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells view
61 1656 954|235203 lipid_droplet High Throughput Imaging Assay for Hepatic Lipid Droplet Formation view
62 720635 1778|4576 mitochondria qHTS assay for small molecule disruptors of the mitochondrial membrane potential view
63 624504 3944|1096 mitochondria Single concentration confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via a fluorescent based assay view
64 720634 372|9165 mitochondria qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability view
65 602449 5040|359127 mitochondria uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay view
66 902 1906|118129 p53 qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature view
67 904 528|50471 p53 qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature view
68 651631 602|6848 p53 qHTS assay for small molecule agonists of the p53 signaling pathway view
69 903 338|52488 p53 qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature view
70 924 1163|119907 p53 qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature view
71 504706 201|302703 p53 qHTS assay for re-activators of p53 using a Luc reporter view
72 624151 414|27150 p53 Luminescence Cell-Based Primary HTS to Identify Re-Activators of the P53 Mutant Pathway Measured in Cell-Based System Using Plate Reader - 2071-01_Activator_SinglePoint_HTS_Activity view
73 651633 748|9015 p53 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability view
74 493208 342|41294 p53 Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon view
75 1663 661|301071 thrombosis MLPCN Platelet Activation -Dense Granule Release view
76 620 364|86393 toxicity Fluorescent HTS Cytotoxicity/Cell viability assay (HT1080 cells) view
77 602340 2587|328400 toxicity HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity view
78 463 706|55782 toxicity Cell Proliferation & view
79 430 1123|61538 toxicity Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) view
80 719 937|83952 toxicity Human Lung Fibroblast Proliferation Assay view
81 431 1068|61592 toxicity Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) view
82 648 925|85244 toxicity Human Endothelial Cell Proliferation Assay in 384-well format view
83 845 387|93853 toxicity Primary HTS assay to asses cytotoxicity for IL-1B stimulated NFkB expression. view
84 504466 4174|306923 toxicity qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 view
85 602141 1309|358211 toxicity uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors view