Searching for gene synergy in triple negative breast cancer

Example 1: ADAM9 and RC3H2

ADAM9 is a membrane-anchored protein and have been implicated in a variety of biological processes as well as has been suggested to be involved in cancer metastasis. RC3H2 is membrane-associated nucleic acid-binding protein. High expression of both genes individually was slightly negatively associated (p-values ~ 0.07 and 0.04) with survival in triple negative patients from METABRIC dataset (see details below). The subgroup of triple negative patients with both genes expressed high has a significant negative shift (p-value < 6e-05) in survival in comparison to other patients (see figure SM1, A). Therefore, SynTarget provides statistical evidences that high expression of both RC3H2 and ADAM9 synergistically affect survival of patients in triple negative cancers.

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Example 2: APOA4 and DEFB104A

Similar, high expression of both genes (APOA4 and DEFB104A) individually was slightly negatively associated (p-values ~ 0.2 and 0.01) with survival in triple negative patients in METABRIC dataset. High expression of both genes has a significant negative shift on survival (p-value < 2.72e-05).

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