AERS spider: an online interactive tool to mine statistical associations in Adverse Event Reporting System.
Grigoriev I, zu Castell W, Tsvetkov P, Antonov AV. Pharmacoepidemiol Drug Saf. 2014 Aug;23(8):795-801.

What is AERS spider?


The Adverse Event Reporting System (AERS) is a largest public collection of adverse events reports. AERS data is valuable resource for exploration of various drug safety issues. However, several questions need to be resolved. First, AERS data must be intensively preprocessed to be converted into analyzable format. Second, several methodological concerns need to be properly addressed. Application of the currently accepted analytical principles leads to a huge number of false positive signals, like, administration of "calcium" significantly increase the risk of various "fractures".

AERS spider

AERS Spider is a public online analytical tool which is based on publicly available AERS data (the data were compiled into unified format to be ready for statistical queries). AERS Spider provides possibility for interactive exploration of "drug to adverse reaction" association pattern by manual/semiautomatic removal from consideration suspicious risk factors (indications, other drugs, age groups). In addition, for the "drug to adverse reaction" association pattern, AERS Spider figure out factors which discriminate "drug and reaction" reports versus "drug and no reaction" reports. These factors are supposed to increase/decrease the risk of the Adverse Reaction if being co-administered with a drug.